Introduction

CancerMHL is a manually-curated database that provides computationally supported key DNA methylation, histone modifications and LncRNAs in cancer. CancerMHL aimed at simplifying the access to these key epigenetic modifications, and promoting the study of disease biomarkers. Specifically,CancerMHL comprises 483 key epigenetic modifications from 9 types of cancer, including 206 DNA methylation sites, 144 histone modification regions, and 133 lncRNAs. Furthermore, CancerMHL offered the distribution patterns of DNA methylation and histone modification in different regions (by mining epigenetic modification data related to cancer). It also provided two online risk assessment tools and an early diagnosis tool for the convenience of medical researchers.

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key DNA methylation sites, histone modifications, and lncRNAs in cancer


Conclusions related to DNA methylation or histone modifications in cancer


Citing

Liu Y X, Li Q Z, Cao Y N, et al. Identification of key genes and important histone modifications in hepatocellular carcinoma[J]. Computational and Structural Biotechnology Journal, 2020, 18: 2657-2669.

Cao Y N, Li Q Z, Liu Y X. Discovered Key CpG Sites by Analyzing DNA Methylation and Gene Expression in Breast Cancer Samples[J]. Frontiers in Cell and Developmental Biology, 2022, 10: 53.

Bai H, Li Q Z, Qi Y C, et al. The prediction of tumor and normal tissues based on the DNA methylation values of ten key sites[J]. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 2022, 1865(6): 194841.

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Citation and Contact

User can cite the database as "Pengyu Du, Yingli Chen*, Qianzhong Li*, Zhimin Gai, Hui Bai, Luqiang Zhang, Yuxian Liu, Yanni Cao, Yuanyuan Zhai and Wen Jin. CancerMHL: the database of integrating key DNA methylation, histone modifications and lncRNAs in cancer. Database-The Journal of Biological Databases and Curation. 2024, baae029, DOI: https://doi.org/10.1093/database/baae029".

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